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The comparative effectiveness and safety of biologic therapies for uncontrolled severe asthma: a systematic review and network meta-analysis
2022-08-08
respiratory medicine
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BackgroundTrials have not directly compared biologics for the treatment of asthma. ObjectiveTo comparative the relative efficacy of biologics in asthma. MethodsWe searched MEDLINE, EMBASE, CENTRAL, and clinicaltrials.gov from inception to May 31, 2022, for randomized trials addressing biologic therapies for asthma. Reviewers worked independently and in duplicate to screen references, extract data, and assess risk of bias. We performed a frequentist network meta-analysis and assessed the certai...
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