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High-throughput mass spectrometry maps the sepsis plasma proteome and differences in response
2022-08-09
intensive care and critical care medicine
Title + abstract only
View on medRxiv
Show abstract
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is an unmet global health challenge. Here we apply high-throughput tandem mass spectrometry to delineate the plasma proteome for sepsis and comparator groups (non-infected critical illness, post-operative inflammation and healthy volunteers) involving 2622 samples and 4553 liquid chromatography-mass spectrometry analyses in a single batch, at 100 samples/day. We show how this scale of data can establi...
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