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An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization
2022-08-06
epidemiology
Title + abstract only
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IntroductionGenetic associations for variants identified through genome-wide association studies (GWAS) tend to be overestimated in the original discovery dataset; as if the association was underestimated, the variant may not have been detected. This bias, known as winners curse, can affect Mendelian randomization estimates, but its severity and potential impact is unclear. MethodsWe performed an empirical investigation to assess the potential bias from winners curse in practice. We considered ...
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