Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
Dai, E. Y.; Lee, K. A.; Nathanson, A. B.; Leonelli, A. T.; Petros, B. A.; Brock-Fisher, T.; Dobbins, S. T.; MacInnis, B. L.; Capone, A.; Littlehale, N.; Boucau, J.; Marino, C.; Barczak, A. K.; Sabeti, P. C.; Springer, M.; Stephenson, K. E.
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We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r significantly reduced time to PCR conversion.
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