Material deprivation is associated with neural resilience for late-life depression
Zhang, W.; Bijsterbosch, J. D.
Show abstract
Late-life depression (LLD) is a major source of global morbidity and mortality, influenced by multiple risk factors. Yet, a major challenge is to quantify the degree of resilience or vulnerability to LLD at the individual level, which could offer neurobiological insight and ultimately inform future interventions and treatment. Here, applying a non-parametric regression model to the UK Biobank data (N=1,988), we quantified brain-based resilience and vulnerability to LLD and tested whether risk factors could explain individual differences in the estimated magnitude of such neural resilience and vulnerability. Our results show that social isolation was positively associated with the median magnitude of neural vulnerability whereas material deprivation was negatively associated with the greatest neural resilience (top 10 percentile). These results together highlight the importance of social interaction and access to sufficient resources and services in diminishing neural vulnerability and promoting neural resilience to LLD, respectively. Our findings therefore provide insights into preventive strategies for LLD, and thus are of importance for policy makers as well as the broader society.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Predicting depression risk in early adolescence via multimodal brain imaging 97%
- Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms 96%
- Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression 95%
Similar papers in this journal
- The Influence of Phenotyping Method on Structural Neuroimaging Associations with Depression in UK Biobank 95%
- Applying Machine-Learning and Deep-Learning to Predict Depression from Brain MRI and Identify Depression-Related Brain Biology 95%
- Importance of test-retest reliability for promoting fMRI based screening and intervention in major depressive disorder 94%
Similar papers in this journal
- Mental health in the UK Biobank: a roadmap to self-report measures and neuroimaging correlates 97%
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis 97%
- Differences in directed functional brain connectivity related to age, sex and mental health 95%
Similar papers in this journal
- Higher amplitudes of visual networks are associated with trait but not state- depression. 96%
- Graded changes in local functional connectivity of the brain in young people with depression 95%
- Brain Functional Connectivity and Anatomical Features as Predictors of Cognitive Behavioral Therapy Outcome for Anxiety in Youths 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.