Back

Computational Causal Discovery for Posttraumatic Stress and Negative Self Image in Young Maltreated Children

Saxe, G. N.; Morales, L. J.; Ma, S.; Urgurbil, M.; Aliferis, C.

2022-07-22 psychiatry and clinical psychology
10.1101/2022.07.20.22277681 medRxiv
Show abstract

ObjectivesThis article features the application of computational causal discovery (CCD) methods to determine the mechanism for Posttraumatic Stress (PTS) in young, maltreated children, in order to advance knowledge for prevention. Advances in prevention require research that identifies causal factors, but the scientific literature that would inform the identification of causes are almost exclusively based on the application of correlational methods to observational data. Causal inferences from such research will frequently be in error. We conducted the present study to explore the application of CCD methods as an alternative - or a supplement - to experimental methods, which can rarely be applied in human research on causal factors for PTS. MethodsA data processing pipeline that integrates state-of-the-art CCD algorithms was applied to an existing observational, longitudinal data set collected by the Consortium for Longitudinal Studies in Child Abuse and Neglect (LONGSCAN). This data set contains a sample of 1,354 children who were identified in infancy to early childhood as being maltreated or at risk. ResultsA causal network model of 251 variables (nodes) and 818 bivariate relations (edges) was discovered, revealing four direct causes and two direct effects for PTS at age 8, within a network containing a broad diversity of causal pathways. Specific causal factors included stress, social, family and development problems: and several of these factors point to promising approaches for prevention. ConclusionsThese results indicate that CCD methods show promise for research on the complex etiology of PTS in young, maltreated children.

Matching journals

The top 9 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.