Computational Causal Discovery for Posttraumatic Stress and Negative Self Image in Young Maltreated Children
Saxe, G. N.; Morales, L. J.; Ma, S.; Urgurbil, M.; Aliferis, C.
Show abstract
ObjectivesThis article features the application of computational causal discovery (CCD) methods to determine the mechanism for Posttraumatic Stress (PTS) in young, maltreated children, in order to advance knowledge for prevention. Advances in prevention require research that identifies causal factors, but the scientific literature that would inform the identification of causes are almost exclusively based on the application of correlational methods to observational data. Causal inferences from such research will frequently be in error. We conducted the present study to explore the application of CCD methods as an alternative - or a supplement - to experimental methods, which can rarely be applied in human research on causal factors for PTS. MethodsA data processing pipeline that integrates state-of-the-art CCD algorithms was applied to an existing observational, longitudinal data set collected by the Consortium for Longitudinal Studies in Child Abuse and Neglect (LONGSCAN). This data set contains a sample of 1,354 children who were identified in infancy to early childhood as being maltreated or at risk. ResultsA causal network model of 251 variables (nodes) and 818 bivariate relations (edges) was discovered, revealing four direct causes and two direct effects for PTS at age 8, within a network containing a broad diversity of causal pathways. Specific causal factors included stress, social, family and development problems: and several of these factors point to promising approaches for prevention. ConclusionsThese results indicate that CCD methods show promise for research on the complex etiology of PTS in young, maltreated children.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Psychosocial family-level mediators in the intergenerational transmission of trauma: Protocol for a systematic review and meta-analysis 92%
- Individual Participant Data Network Meta-analysis of psychosocial interventions for survivors of intimate partner violence: Study protocol 92%
- Time-to-event estimation of birth year prevalence trends: a method to enable investigating the etiology of childhood disorders including autism 91%
Similar papers in this journal
- Predicting involuntary admission following inpatient psychiatric treatment using machine learning trained on electronic health record data 92%
- A Comparison of Pruning During Multi-Step Planning in Depressed and Healthy Individuals 90%
- A computational approach to understanding effort-based decision-making in depression 90%
Similar papers in this journal
- A Bayesian predictive approach for dealing with pseudoreplication 93%
- Widely accessible prognostication using medical history for fetal growth restriction and small for gestational age in nationwide insured women 91%
- Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations 91%
Similar papers in this journal
Similar papers in this journal
- Differential Treatment Benefit Prediction For Treatment Selection in Depression: A Deep Learning Analysis of STAR*D and CO-MED Data 92%
- Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders 91%
- Anxiety, avoidance, and sequential evaluation 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.