Sleep cycle-dependent vascular dynamics enhance perivascular cerebrospinal fluid flow and solute transport
Bojarskaite, L.; Bjornstad, D. M.; Vallet, A.; Binder, K. M. G.; Cunen, C.; Heuser, K.; Kuchta, M.; Mardal, K.-A.; Enger, R.
Show abstract
Perivascular spaces (PVS) are important highways for fluid and solute transport in the brain enabling efficient waste clearance during sleep. Using two-photon imaging of naturally sleeping mice we demonstrate sleep cycle-dependent PVS dynamics - slow, large-amplitude oscillations in NREM, a reduction in REM and an enlargement upon awakening at the end of a sleep cycle. By biomechanical modeling we demonstrate that these sleep cycle-dependent PVS dynamics drive fluid flow and solute transport.
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