VSTM1-v2 does not drive human Th17 cell differentiation
von Richthofen, H. J.; Hafkamp, F. M. J.; van Haperen, A.; de Jong, E. C.; Meyaard, L.
Show abstract
Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an immune inhibitory receptor expressed on human myeloid cells. We previously showed that dendritic cell (DC)-driven Th17 cell differentiation of human naive CD4+ T cells requires presence of neutrophils, which is inhibited by SIRL-1 ligation. VSTM1-v2 is a soluble isoform of SIRL-1, which was previously proposed to function as a Th17 polarizing cytokine. Here, we investigated the effect of VSTM1-v2 on DC-driven Th17 cell development. Neutrophils induced DC-driven Th17 cell differentiation, which was not enhanced by VSTM1-v2. Similarly, we found no effect of VSTM1-v2 on cytokine-driven Th17 cell development. Thus, our results do not support a role for VSTM1-v2 in Th17 cell differentiation.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Levamisole suppresses activation and proliferation of human T cells by the induction of a p53-dependent DNA damage response 94%
- Regulation of B cell function and expression of CD11c, T-bet, and FcRL5 in response to different activation signals 93%
- Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation 93%
Similar papers in this journal
- Conserved epigenetic programming and enhanced heme metabolism drive memory B cell reactivation 94%
- Investigation of fascin1, a marker of mature dendritic cells, reveals a New role for IL-6 signaling in chemotaxis. 94%
- Human CD8+ T cells exhibit a shared antigen threshold for different effector responses 94%
Similar papers in this journal
- Generation and utilization of a HEK-293T murine GM-CSF expressing cell line 95%
- The Ca2+ concentration in vitro impacts the cytokine production of mouse and human lymphoid cells and the polarization of human macrophages 94%
- Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation. 94%
Similar papers in this journal
- Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons 94%
- Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum 93%
- Mouse Memory CD8 T cell subsets defined by Tissue Resident Memory (TRM) Integrin Expression Exhibit Distinct Metabolic Profiles 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.