Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging
Storey, C. M.; Altai, M.; Bicak, M.; Veach, D. R.; Lueckerath, K.; Adrian, G.; McDevitt, M. R.; Kalidindi, T.; Park, J. E.; Herrmann, K.; Abou, D.; Zedan, W.; Peekhaus, N.; Klein, R. J.; Damoiseaux, R.; Larson, S. M.; Lilija, H.; Thorek, D.; Thorek, D. L.; Ulmert, D.
Show abstract
External beam radiotherapy (EBRT) remains a common treatment for all stages of PCa, but DNA damage induced by EBRT upregulates androgen receptor (AR) pathway activity to promote therapeutic resistance. [89Zr]11B6-PET is a novel modality targeting prostate-specific protein human kallikrein 2 (hK2), which is a surrogate biomarker for AR activity. Here, we studied if [89Zr]11B6-PET can accurately assess EBRT-induced AR activity. PCa mouse models received EBRT (2-50 Gy) and treatment response was monitored by [89Zr]11B6-PET/CT. Radiotracer uptake and expression of AR and AR target genes was quantified in resected tissue. EBRT increased AR pathway activity in LNCaP-AR tumors. EBRT increased prostate-specific [89Zr]11B6 uptake and hK2 levels in PCa-bearing mice (Hi-Myc x Pb_KLK2) with no significant changes in uptake in healthy (Pb_KLK2) mice. Thus, [89Zr]11B6-PET specifically detects activation of AR pathway activity after EBRT in PCa. Further clinical evaluation of hK2-PET for monitoring EBRT is warranted.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe 93%
- Improving SBRT by re-wiring immunosuppressive neutrophils in murine pancreatic ductal adenocarcinoma 93%
- Risk of Clonal Hematopoiesis of Indeterminate Potential after Cancer Radiation Therapy 92%
Similar papers in this journal
- -Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response 96%
- Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models 92%
- Intermittent radiotherapy as alternative treatment for recurrent high grade glioma: A modelling study based on longitudinal tumor measurements 92%
Similar papers in this journal
- PSMA+ Extracellular Vesicles are a Biomarker for SABR in Oligorecurrent Prostate Cancer Analysis from the STOMP-like and ORIOLE trial cohorts 92%
- Human Papilloma Virus Circulating Cell-Free DNA Kinetics in Cervical Cancer Patients Undergoing Definitive Chemoradiation 91%
- MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma 90%
Similar papers in this journal
- Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition 95%
- Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance 92%
- High-resolution positron emission microscopy of patient-derived tumor organoids 90%
Similar papers in this journal
- SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model 91%
- Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma 91%
- Avasopasem Manganese acts as both a Radioprotector and a Radiomitigator of Radiation-Induced Acute or Late Effects. 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.