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Cancer cells survival is dependent on the lincRNA JUNI

Shaulian, E.; Kumar, V.; Soni, I.; Stern, E.; Ginsberg, D.; Dodel, M.; Mardakheh, F. K.; Vias, C.; Sabate-Cadenas, X.; Shkumatava, A.

2022-06-21 cell biology
10.1101/2022.06.21.496924 bioRxiv
Show abstract

Identification of key factors for cellular survival is a basis for therapy. We identified JUNI (linc01135) as a stress-regulated lncRNA, essential for cell survival and implicated in cancer. Besides regulating c-Jun expression we demonstrate c-Jun-independent, robust requirement for cell survival. Analysis of median survival of cancer patients suffering from various types of cancer reveals correlations of JUNI expression levels with alterations in patients survival. JUNIs antagonistic interaction with DUSP14, a negative regulator of the JNK pathway, underlies the regulation of c-Jun and partial effects on cellular survival. Consistently, DUSP14 expression is coherently inversely-correlated with the survival of patients suffering from the same types of cancer. Our data suggests that JUNI is a novel master regulator of cell fate. SummaryJUNI is a novel regulator of cell survival, JNK activation and c-Jun expression, implicated in survival of cancer patients

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