Meta-Analysis of Genome-Wide Association Studies of Hoarding Symptoms in 27 537 Individuals
Strom, N. I.; Smit, D. J.; Silzer, T.; Iyegbe, C.; Burton, C. L.; Pool, R.; Lemire, M.; Crowley, J. J.; Hottenga, J.-J.; Ivanov, V. Z.; Larsson, H.; Lichtenstein, P.; Magnusson, P.; Rück, C.; Schachar, R.; Wu, H. M.; Meier, S. M.; Crosbie, J.; Arnold, P. D.; Mattheisen, M.; Boomsma, D.; Mataix-Cols, D.; Cath, D.
Show abstract
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27 537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we found a significant contribution of common genetic factors to HS, as indicated by substantial SNP-based twin-heritability estimates ranging between 26% and 48% and a SNP-heritability of 11% for one sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a "gene discovery zone". To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology 95%
- Evidence of shared genetic influences underlying schizophrenia and alcohol use disorder, but not alcohol consumption 94%
- A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra 94%
Similar papers in this journal
- Schizophrenia Risk Alleles Often Affect The Expression of Many Genes and Each Gene May Have a Different Effect On The Risk; A Mediation Analysis. 94%
- Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder 94%
- TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders 93%
Similar papers in this journal
- Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation 94%
- Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder 94%
- Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use 94%
Similar papers in this journal
- Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium 94%
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development 94%
- Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems 94%
Similar papers in this journal
- Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention deficit hyperactivity disorder 93%
- Polygenic profiles define aspects of clinical heterogeneity in ADHD 93%
- Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.