DivIVA phosphorylation at threonine affects its dynamics and cell cycle in Deinococcus radiodurans.
Chaudhary, R.; kota, S.; Misra, H. S.
Show abstract
RqkA, a {gamma} radiation responsive Ser/Thr quinoprotein kinase, is characterized for its role in radioresistance in Deinoocccus radiodurans. DivIVA is a cell division protein involved in determination of cell pole and division site in bacteria. RqkA phosphorylated cognate DivIVA (drDivIVA) at Threonine 19 (T19) residue located in its pole recognition motif. The phospho-mimetic replacement of T19 (T19E) functioned differently than phospho-ablative (T19A) and drDivIVA proteins. T19E-RFP expressing in wild type background showed arrest in dynamics of drDivIVA, and loss of interaction with genome segregation protein. divIVA is shown to be an essential gene in this bacterium. The allelic replacement of divIVA with T19E-RFP was not tolerated unless drDivIVA was expressed episomally while there was no effect of this replacement with T19A-RFP and drDivIVA-RFP. These results suggested that the T19 phosphorylation in drDivIVA by RqkA has affected in vivo functions of DivIVA that would render cell cycle arrest in this bacterium.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Identification of the unwinding region in the Clostridioides difficile chromosomal origin of replication 93%
- Small RNA profiling in Mycobacterium insights into stress adapt ability 93%
- Functional insights from KpfR, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity 93%
Similar papers in this journal
- The interplay between the polar growth determinant DivIVA, the segregation protein ParA and their novel interaction partner PapM controls the Mycobacterium smegmatis cell cycle by modulation of DivIVA subcellular distribution 94%
- Characterization of DNA processing protein A (DprA) of the radiation-resistant bacterium Deinococcus radiodurans 94%
- Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination 93%
Similar papers in this journal
- Characterization Of Recombinase Activity Across Cellular Growth Phases 92%
- A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts 92%
- Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell 91%
Similar papers in this journal
Similar papers in this journal
- Formation of multiple flagella caused by a mutation of the flagellar rotor protein FliM in Vibrio alginolyticus 90%
- Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain 90%
- An ALS-associated mutant KIF5A forms oligomers and aggregates and induces neuronal toxicity 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.