Correlations Between EEG Spectral Power and Cerebral Perfusion in Adults Undergoing Extracorporeal Membrane Oxygenation
Khan, I. R.; Dar, I. A.; Johnson, T. W.; Loose, E.; Xu, Y. Y.; Santiago, E.; Donohue, K. L.; Marinescu, M. A.; Gosev, I.; Schifitto, G.; Choe, R.; Selioutski, O.
Show abstract
ObjectivePatients with acute lung or heart failure can experience hypoxic ischemic brain injury resulting in neurovascular unit (NVU) dysfunction. The NVU couples brain activity and perfusion. Extracorporeal membrane oxygenation (ECMO) is used for refractory lung and/or heart failure and often necessitates sedation, obfuscating neurological assessments. We hypothesized that combining cerebral electrographic activity and perfusion monitoring can detect brain injury in adults undergoing ECMO. MethodsFast Fourier transformation was used to identify fast (+{beta}) and slow ({delta}) power bands from cEEG. Diffuse correlation spectroscopy (DCS) measured blood flow index (BFI), a surrogate of perfusion, daily in adults undergoing ECMO. Correlations between +{beta}/{delta} ratio (ABDR) and BFI were compared between patients who were grouped into brain-injured and uninjured groups by neurologic exam and neuroimaging findings. ResultsTen patients (21-78 years old, five females, five brain-injured) underwent cEEG and DCS monitoring. Sixty-eight monitoring sessions (average 127 minutes/session) were analyzed. ABDR-BFI correlation was significantly higher in uninjured patients than brain-injured ones. Sedation did not significantly impact CBF-power band correlation. ConclusionsBrain-injured patients exhibited significantly less correlation between brain activity and perfusion, possibly as a result of NVU dysfunction. SignificanceABDR-BFI correlation can be measured continuously and noninvasively at the bedside and may represent a marker of NVU dysfunction. HighlightsO_LIQuantitative EEG and diffuse correlative spectroscopy can be used to measure markers of brain injury noninvasively, continuously, and at the bedside. C_LIO_LIDecreased ABDR-BFI correlation may be a marker of neurovascular decoupling in patients with hypoxic ischemic brain injury. C_LIO_LIABDR-BFI correlation may be independent of analgosedation, which is used heavily in patients undergoing ECMO. C_LI
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Reference values for amplitude-integrated EEGs in children from 1 month to 17 years of age 94%
- Seizure Forecasting Using a Novel Sub-Scalp Ultra-Long Term EEG Monitoring System 92%
- Towards individualized Medicine in Stroke – the TiMeS project: protocol of longitudinal, multi-modal, multi-domain study in stroke 91%
Similar papers in this journal
- Increased interhemispheric asymmetry of cerebral blood flow in comatose adult patients on extracorporeal membrane oxygenation 95%
- Dexmedetomidine - commonly used in functional imaging studies - increases susceptibility to seizures in rats but not in wild type mice 93%
- Changes in interictal pretreatment and posttreatment EEG in childhood absence epilepsy 92%
Similar papers in this journal
- Numerical Simulation of Concussive-generated Cortical Spreading Depolarization to Optimize DC-EEG Electrode Spacing for Non-invasive Visual Detection 93%
- Early intravenous Beta-Blockade with esmolol in adults with isolated severe Traumatic Brain Injury (EBB-TBI): protocol for a phase 2a intervention design study 91%
- Isofurans and isoprostanes as markers of delayed brain injury and mitochondrial dysfunction following aneurysmal subarachnoid hemorrhage. A prospective observational study 91%
Similar papers in this journal
- Brain-heart interactions are associated with mortality and acute encephalopathy in ICU patients with severe COVID-19 93%
- EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery. 93%
- Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone 93%
Similar papers in this journal
- An affordable solution for investigating zebra finch intracranial electroencephalography (iEEG) signals 93%
- Wavelet Phase Coherence of Ictal Scalp EEG-Extracted Muscle Activity (SMA) as a Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP) 93%
- Characteristic changes in EEG spectral powers of patients with opioid-use disorder as compared with those with methamphetamine- and alcohol-use disorders 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.