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Long COVID is associated with extensive in-vivo neuroinflammation on DPA-714 PET

Visser, D.; Golla, S. S. V.; Verfaillie, S. C. J.; Coomans, E. M.; Rikken, R. M.; van de Giessen, E. M.; den Hollander, M. E.; Verveen, A.; Yaqub, M.; Barkhof, F.; Horn, J.; Koopman, B.; Schober, P.; Koch, D. W.; Schuit, R. C.; Windhorst, A. D.; Kassiou, M.; Boellaard, R.; van Vugt, M.; Knoop, H.; Tolboom, N.; van Berckel, B. N. M.

2022-06-04 infectious diseases
10.1101/2022.06.02.22275916 medRxiv
Show abstract

A significant number of COVID-19 patients develop long COVID, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, using a quantitative assessment, [18F]DPA-714 PET, in two long COVID patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both patients with long COVID had widespread increases in [18F]DPA-714 binding throughout the brain. Quantitative measures of binding (BPND values) were increased on average by 121% and 76%, respectively. This implicates profound neuroinflammation in the pathophysiology of long COVID.

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