Integrated placental modelling of histology with gene expression to identify functional impact on fetal growth
Yong, H. E. J.; Maksym, K.; Yusoff, M. A. B.; Salazar-Petres, E.; Nazarenko, T.; Zaikin, A.; David, A.; Hillman, S. L.; Sferruzzi-Perri, A. N.
Show abstract
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation and functional capacity are major contributors to FGR pathogenesis. Relating placental structure to function across the placenta in healthy and FGR pregnancies remains largely unexplored but could improve understanding of placental diseases. We investigated integration of these parameters spatially in the term human placenta using predictive modelling. Systematic sampling was able to overcome heterogeneity in placental morphological and molecular features. Defects in villous development, elevated fibrosis, and reduced expression of growth and functional marker genes (IGF2, VEGA, SLC38A1, SLC2A3) were seen in age-matched term FGR versus healthy control placentas. Characteristic histopathological changes with specific accompanying molecular signatures could be integrated through computational modelling to predict if the placenta came from a healthy or FGR pregnancy. Our findings yield new insights into the spatial relationship between placental structure and function and the aetiology of FGR.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Association of Deep Learning-Derived Histologic Features of Placental Chorionic Villi with Maternal and Infant Characteristics in the New Hampshire Birth Cohort Study 97%
- SARS-CoV-2 infection disrupts syncytial and endothelial integrity and alters PLGF levels in the placenta 96%
- Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes 96%
Similar papers in this journal
- Stratifying IVF population endometria using a prognosis gradient independent of endometrial timing. 93%
- The effect of the menstrual cycle on the circulating microRNA pool in human plasma: a pilot study 92%
- Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy 92%
Similar papers in this journal
- Pregnancy-induced changes in blood composition drive post-partum hemorrhage risk 94%
- Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses 93%
- Identification of novel nutrient-sensitive human yolk sac functions required for embryogenesis 93%
Similar papers in this journal
- Increased Circulating miR-155 identifies a subtype of preeclamptic patients 93%
- Comparison of first trimester dating methods for gestational age estimation and their implication on preterm birth classification in a North Indian cohort 93%
- Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study 91%
Similar papers in this journal
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births 97%
- Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia 95%
- Placental vascular remodeling in pregnant women with COVID-19 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.