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Sputum alarmin levels delineate distinct T2 cytokine pathways and patient subgroups in asthma
2022-05-30
respiratory medicine
Title + abstract only
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RationaleAsthma is a chronic airway disease driven by multiple immunologic pathways that determine the clinical response to therapy. Current diagnostic methods are incapable of discriminating subtypes of asthma and guiding targeted treatment. We hypothesized that sputum cytokine profiles could help to identify immunologically-defined disease subtypes and individualize therapy in patients with severe asthma. ObjectivesDefine asthma subtypes associated with sputum alarmin and cytokine levels. Me...
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