The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution
Nair, S.; Barrett, A.; Li, D.; Raney, B. J.; Lee, B. T.; Kerpedjiev, P.; Ramalingam, V.; Pampari, A.; Lekschas, F.; Wang, T.; Haeussler, M.; Kundaje, A.
Show abstract
We introduce the dynseq genome browser track, which displays DNA nucleotide characters scaled by user-specified, base-resolution scores provided in the BigWig file format. The dynseq track enables visualization of context-specific, informative genomic sequence features. We demonstrate its utility in three popular genome browsers for interpreting cis-regulatory sequence syntax and regulatory variant interpretation by visualizing nucleotide importance scores derived from machine learning models of regulatory DNA trained on protein-DNA binding and chromatin accessibility experiments.
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