Antiviral activity of the hemolymph of Podalia sp and M. albicolis (Lepidoptera: Megalopigydae)
Carvalho, N. D.; Curti, S. P.; Oliveira, M. I.; Rofatto, H. K.; Figueiredo, C. A.; Sena de Villar, K.; Magnelli, R. F.; Mendonca, R. Z.
Show abstract
Potent antiviral activity against measles, influenza, picornavirus and herpes simplex viruses was observed in the hemolymph of Podalia sp and M. Albicolis (Lepidoptera: Megalopigydae). The antiviral proteins responsible for this activity were isolated by gel filtration chromatography using a gel filtration column system (Superdex 75) and further fractionated using a Resource-Q ion exchange column system. Experiments with the semi-purified protein led to a 128-fold reduction in picornavirus production, 64-fold reduction in measles virus production and a 32-fold reduction in influenza virus replication. qPCR showed a significantly lower level of herpes virus transcription. In addition no citotoxicity and genotoxicity effect was observed for Vero cells, suggesting a very interesting potential antiviral activity.
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