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Computational conjugate adaptive optics for longitudinal through-skull imaging of cortical myelin

Kwon, Y.; Hong, J. H.; Yoon, S.; Kang, S.; Lee, H.; Jo, Y.; Kim, K. H.; Choi, W.

2022-05-20 neuroscience
10.1101/2022.05.18.492378 bioRxiv
Show abstract

We present a 1.3-m reflection matrix microscope and computational conjugate adaptive optics algorithm for label-free longitudinal imaging of cortical myelin through an intact mouse skull. The myelination processes of the same mice were observed from 3 to 10 postnatal weeks down to cortical layer 4 with a near-diffraction-limited resolution of 0.79 {micro}m. Our system will expedite the investigations on the role of myelination in learning, memory, and brain disorders.

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