Borg tandem repeats undergo rapid evolution and are under strong selection to create new intrinsically disordered regions in proteins
Schoelmerich, M. C.; Sachdeva, R.; Waldburger, L.; West-Roberts, J.; Banfield, J.
Show abstract
Borgs are huge, linear extrachromosomal elements associated with anaerobic methane-oxidizing archaea. Striking features of Borg genomes are pervasive tandem direct repeat (TR) regions. Here, we present six new Borg genomes and investigate the characteristics of tandem repeats in all ten complete Borg genomes. We find that TR regions are rapidly evolving, recently formed, arise independently and are virtually absent in host Methanoperedens genomes. Flanking partial repeats and A-enriched character constrain the TR formation mechanism. TRs can be in intergenic regions, where they might serve as regulatory RNAs, or in open reading frames (ORFs). TRs in ORFs are under very strong selective pressure, leading to perfect amino acid TRs (aaTRs) that are commonly intrinsically disordered regions. Proteins with aaTRs are often extracellular or membrane proteins, and functionally similar or homologous proteins often have aaTRs composed of the same amino acids. We propose that Borg aaTR-proteins functionally diversify Methanoperedens and all TRs are crucial for specific Borg-host associations and possibly co-speciation.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Symbiosis genes show a unique pattern of introgression and selection within a Rhizobium leguminosarum species complex 95%
- Meta Analysis of the Ralstonia solanacearum species complex (RSSC) based on comparative evolutionary genomics and reverse ecology 95%
- The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant 94%
Similar papers in this journal
- On the Evolution of Chromosomal Regions with High Gene Strand Bias in Bacteria 95%
- Toxinome - The Bacterial Protein Toxin Database 93%
- The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism 93%
Similar papers in this journal
- Role of Diversity-Generating Retroelements for Regulatory Pathway Tuning in Cyanobacteria 95%
- Diversity and dynamics of the CRISPR-Cas systems associated with Bacteroides fragilis in human population 94%
- GeneMates: an R package for Detecting Horizontal Gene Co-transfer between Bacteria Using Gene-gene Associations Controlled for Population Structure 94%
Similar papers in this journal
- A cryptic transcription factor regulates Caulobacter adhesin development 94%
- A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities 94%
- Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumanniicomplex 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.