Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection
Ricciardi, M. J.; Rust, L. N.; Pedreno-Lopez, N.; Yusova, S.; Biswas, S.; Webb, G. M.; Fischer, M.; Gonsales-Nieto, L.; Voigt, T. B.; Louw, J. J.; Laurino, F. D.; DiBello, J. R.; Raue, H.-P.; Raphael, L. M. S.; Yrizarry-Medina, A.; Rosen, B. C.; Agnor, R.; Gao, L.; Labriola, C.; Axthelm, M.; Smedley, J.; Julander, J. G.; Bonaldo, M. C.; Walker, L. M.; Slifka, M. K.; Messaoudi, I.; Burton, D. R.; Kallas, E. G.; Sacha, J. B.; Watkins, D. I.; Burwitz, B. J.
Show abstract
Few countermeasures to treat Yellow Fever virus (YFV) infection are under development, because vaccines have helped to limit new infections. Unfortunately, vaccine hesitancy, supply deficits, and a paucity of therapeutic options have left individuals at risk. Here, we tested potent YFV-specific neutralizing monoclonal antibodies in rodents and non-human primates. We administered antibodies during acute pathogenic YFV infection and demonstrate that we can prevent severe disease and death. Given the severity of YFV-induced disease, our results show that these antibodies could be effective in saving lives and fill a much-needed void in managing Yellow Fever cases during outbreaks around the world. One Sentence SummaryTherapeutic monoclonal antibodies prevent death from YFV infection.
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