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On the bacterial ancestry of mitochondria: new insights with triangulated approaches

Esposti, M. D.; Geiger, O.; Sanchez-Flores, A. F.; Esposti, M. D.

2022-05-16 evolutionary biology
10.1101/2022.05.15.491939 bioRxiv
Show abstract

We breathe at the molecular level when mitochondria in our cells consume oxygen to extract energy from nutrients. Mitochondria are characteristic cellular organelles that derive from aerobic bacteria similar to some of those thriving in the oceans nowadays. These organelles carry out most metabolic pathways in eukaryotic cells. The precise bacterial origin of mitochondria and, consequently, the metabolic ancestry of our cells remains controversial - despite the vast genomic information that is now available. Here we triangulate across multiple phylogenomic and molecular approaches to pinpoint the most likely living relatives of the ancestral bacteria from which mitochondria originated.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.