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Linking GWAS to pharmacological treatments for psychiatric disorders
2022-05-16
psychiatry and clinical psychology
Title + abstract only
View on medRxiv
Show abstract
ImportanceLarge-scale genome-wide association studies (GWASs) are expected to inform the development of pharmacological treatments, however the mechanisms of correspondence between the genetic liability identified through GWASs and disease pathophysiology are not well understood. ObjectiveTo investigate whether functional information from a range of open bioinformatics datasets can elucidate the relationship between GWAS-identified genetic variation and the genes targeted by current treatments ...
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