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Genomic summary statistics and meta-analysis for set-based gene-environment interaction tests in large-scale sequencing studies

2022-05-10 genetic and genomic medicine Title + abstract only
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We propose an efficient method to generate the summary statistics for set-based gene-environment interaction tests, as well as a meta-analysis approach that aggregates the summary statistics across different studies, which can be applied to large biobank-scale sequencing studies with related samples. Simulations showed that meta-analysis is numerically concordant with the equivalent pooled analysis using individual-level data. Moreover, meta-analysis accommodates heterogeneity between studies an...

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