Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta
Grint, D. J.; Wing, K.; Gibbs, H. P.; Evans, S. J.; Williamson, E. J.; Bhaskaran, K.; McDonald, H. I.; Walker, A. J.; Evans, D.; Hickman, G.; Mathur, R.; Schultze, A.; Rentsch, C. T.; Tazare, J.; Douglas, I. J.; Curtis, H. J.; Morton, C. E.; Bacon, S. C.; Davy, S.; MacKenna, B.; Inglesby, P.; Croker, R.; Parry, J.; Hester, F.; Harper, S.; DeVito, N. J.; Hulme, W. J.; Bates, C.; Cockburn, J.; Mehrkar, A.; Goldacre, B.; Eggo, R. M.; Tomlinson, L.
Show abstract
The SARS-CoV-2 Omicron variant is increasing in prevalence around the world. Accurate estimation of disease severity associated with Omicron is critical for pandemic planning. We found lower risk of accident and emergency (AE) attendance following SARS-CoV-2 infection with Omicron compared to Delta (HR: 0.39 (95% CI: 0.30 - 0.51; P<.0001). For AE attendances that lead to hospital admission, Omicron was associated with an 85% lower hazard compared with Delta (HR: 0.14 (95% CI: 0.09 - 0.24; P<.0001)). Conflicts of InterestsNothing to declare. Funding statementThis work was supported by the Medical Research Council MR/V015737/1. TPP provided technical expertise and infrastructure within their data centre pro bono in the context of a national emergency. Rosalind Eggo is funded by HDR UK (grant: MR/S003975/1), MRC (grant: MC_PC 19065), NIHR (grant: NIHR200908).
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Direct and indirect mortality impacts of the COVID-19 pandemic in the US, March 2020-April 2021 92%
- SARS-CoV-2 transmission dynamics in South Africa and epidemiological characteristics of the Omicron variant 91%
- Social Contact Patterns and Implications for Infectious Disease Transmission: A Systematic Review and Meta-Analysis of Contact Surveys 91%
Similar papers in this journal
- Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population 94%
- Effectiveness of ChAdOx1-S COVID-19 Booster Vaccination against the Omicron and Delta variants in England 93%
- A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk 93%
Similar papers in this journal
- SARS-CoV-2 incidence, transmission and reinfection in a rural and an urban setting: results of the PHIRST-C cohort study, South Africa, 2020-2021 92%
- Protection against Omicron re-infection conferred by prior heterologous SARS-CoV-2 infection, with and without mRNA vaccination 92%
- Post-vaccination SARS-CoV-2 infection: risk factors and illness profile in a prospective, observational community-based case-control study 92%
Similar papers in this journal
- Symptom reporting in over 1 million people: community detection of COVID-19 93%
- Outcome of COVID-19 in hospitalised immunocompromised patients: an analysis of the WHO ISARIC CCP-UK prospective cohort study 92%
- Global epidemiology of SARS-CoV-2 infection: a systematic review and meta-analysis of standardized population-based seroprevalence studies, Jan 2020-Dec 2021 91%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.