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The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumption

2022-05-03 epidemiology Title + abstract only
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Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure of interest (violating the exclusion restriction assumption). We demonstrate use of a global randomization test as a falsification test for the exclusion restriction assumption. Using simulations, we explored the statistical power of the randomization test to detect an association between a genetic instrument and a covariate set due to a) selection bias or b) horizontal plei...

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