Snip1-PRC2 governs the intrinsic apoptosis program in the developing brain
Matsui, Y.; Djekidel, M. N.; Lindsay, K.; Samir, P.; Connolly, N.; Chen, H.; Fan, Y.; Xu, B.; Peng, J. C.
Show abstract
Brain development requires the intricate balance between division, death, and differentiation of neural progenitor cells (NPCs). Here, we report the discovery of Snip1 as a key regulator of these NPC phases. The conditional deletion of Snip1 in the mouse embryonic brain causes dysplasia with robust induction of caspase 9-dependent apoptosis. In NPCs, Snip1 suppresses the genetic programs of apoptosis and developmental signaling pathways and promotes the genetic programs of cell cycle, neurogenesis, and cortical development. Mechanistically, Snip1 binds to the Polycomb complex PRC2, co-occupies gene targets with PRC2, and regulates H3K27 marks. Deletion of PRC2 is sufficient to reduce apoptosis and brain dysplasia and partially restore genetic programs and tissue development in the Snip1-depleted brain. Our findings suggest that Snip1 exerts loci-dependent regulation of PRC2 and H3K27me3 to toggle between cell fates in the developing brain.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia 95%
- St18 specifies globus pallidus projection neuron identity in MGE lineage 95%
- The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome 95%
Similar papers in this journal
- Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis 94%
- Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins 94%
- CTNND2 regulation by the SRGAP2 protein family links human evolution to synaptic neoteny 94%
Similar papers in this journal
- The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex 97%
- Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence 96%
- Independent control of neurogenesis and dorsoventral patterning by NKX2-2 94%
Similar papers in this journal
- CTCF-RNA interactions orchestrate cell-specific chromatin loop organization 94%
- Integrated single-cell transcriptomic and epigenetic analyses of cell-state transition and lineage commitment in the embryonic mouse cerebellum 94%
- Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.