COVID-19 third wave experience in India, a survey of 5971 adults

BackgroundThe third wave of the pandemic in India lasted from January till March 2022, and breakthrough infections were common. Third dose of vaccine was rolled out to priority groups in the beginning of 2022. There is no published information available about the clinical outcomes in this context. AimsO_LITo assess the community level experience of the pandemic, with focus on the third wave and vaccination in India. C_LIO_LITo describe the experience of the boosted and non-boosted population during the 3rd wave. C_LIO_LITo study the public perception about the precautionary (3rd) dose in India. C_LI ResultsAmong 5971 respondents, 98.6% were vaccinated, 40% of whom had also received the 3rd dose. Age range: 24% were below 40, 50% were 40-59, 26% were >60 years. 45% were women, 53% were healthcare workers. COVID-19 was reported by 3361 (56%) respondents. Among those who reported COVID-19, 2311 (70%) were infected during the third wave. Severe symptoms occurred in <1%, while moderate severity was reported by 42%. Repeated bouts of infection were common; 15% of those with a history of COVID-19 had been infected at least twice. 44% of the respondents (2610/5971) did not report a history of COVID-19. The third dose was taken by 2383 individuals, of whom 30% reported COVID-19 during the 3rd wave. The boosted group also had higher N95 use, and a greater proportion of healthcare workers. Among those who did not take a 3rd dose, 45% reported COVID-19 in the 3rd wave. COVID-19 incidence was lower at 27% among those in this group who had recently received their second dose. Longer gap after the second dose correlated with higher chance of infection during 3rd wave. Giving a 3rd dose before a 6-month gap since the second dose did not make a difference in infection rate. Covaxin and Covishield recipients had the same incidence of COVID-19 during the third wave. While 35% of the respondents believed it was helpful, 65% of the respondents were either uncertain or disapproving of the benefit of a 3rd dose. ConclusionsO_LI30% of respondents who received a 3rd dose went on to get COVID-19 during the 3rd wave. C_LIO_LIYounger adults were more likely to be affected during 3rd wave. C_LIO_LIAlthough severe disease was rare, 42% reported having symptoms of moderate severity that could temporarily incapacitate people, affecting their routine and productivity. C_LIO_LIThe proportion of different grades of severity was similar among all vaccinated people, regardless of whether they received a 3rd dose. C_LIO_LIReinfections occurred in 15%, and were not always milder. C_LIO_LIAmong those who did not receive a 3rd dose, 45% reported COVID-19 in the 3rd wave. However, this group had lower use of N95 masks (50%) than the 3rd dose group (68%) which may have reduced the overall protection. C_LIO_LIThe longer the gap after the second dose, the greater was the chance of reporting COVID-19. C_LIO_LIPeople who received their second dose recently had the same incidence of third wave COVID-19 as following a 3rd dose. C_LIO_LIThe 3rd dose, given too close to the second dose, made no difference in the infection rate. C_LIO_LICovaxin and Covishield recipients had the same rate of COVID-19 in the third wave. C_LIO_LIAlthough the respondents were 98.6% vaccinated at baseline, there was considerable uncertainty (65%) amongst them about the benefit of a 3rd dose. C_LI