Early dosage compensation of zygotically-expressed genes in Drosophila melanogaster is mediated through a post-transcriptional regulatory mechanism
Blake, V. M.; Eisen, M.
Show abstract
Many key regulators of early embryogenesis in Drosophila melanogaster are X-linked. However, the canonical, MSL-mediated dosage compensation, which involves hyper-transcription of the genes on the single X chromosome in males, is not active until the post-syncytial stage of development. A separate MSL-independent dosage compensation system active earlier in development has been described, though the mechanism through which the process functions remain unclear. In this study, we quantified transcription in living embryos at single-locus resolution to determine if early dosage compensation of the X-linked genes buttonhead and giant is sensitive to X chromosome dose. We found no evidence for a transcriptionally regulated mechanism of early dosage compensation, suggesting that the previously observed compensation of mRNA levels for these genes is achieved via a post-transcriptional regulatory mechanism.
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