Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence
Kopal, J.; Kumar, K.; Saltoun, K.; Modenato, C.; Moreau, C. A.; Martin-Brevet, S.; Huguet, G.; Jean-Louis, M.; Martin, C.-O.; Saci, Z.; Younis, N.; Tamer, P.; Douard, E. A.; Maillard, A.; Rodriguez-Herreros, B.; Pain, A.; Richetin, S.; Kushan, L.; Silva, A. I.; van den Bree, M. B.; Linden, D. E.; Owen, M. J.; Hall, J.; Lippe, S.; Draganski, B.; Sonderby, I. E.; Andreassen, O. A.; Glahn, D. C.; Thompson, P.; Bearden, C. E.; Jacquemont, S.; Bzdok, D.
Show abstract
Copy number variations (CNVs) are rare genomic deletions and duplications that can exert profound effects on brain and behavior. Previous reports of pleiotropy in CNVs imply that they converge on shared mechanisms at some level of pathway cascades, from genes to large-scale neural circuits to the phenome. However, studies to date have primarily examined single CNV loci in small clinical cohorts. It remains unknown how distinct CNVs escalate the risk for the same developmental and psychiatric disorders. Here, we quantitatively dissect the impact on brain organization and behavioral differentiation across eight key CNVs. In 534 clinical CNV carriers from multiple sites, we explored CNV-specific brain morphology patterns. We extensively annotated these CNV-associated patterns with deep phenotyping assays through the UK Biobank resource. Although the eight CNVs cause disparate brain changes, they are tied to similar phenotypic profiles across [~]1000 lifestyle indicators. Our population-level investigation established brain structural divergences and phenotypical convergences of CNVs, with direct relevance to major brain disorders.
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