The specific roles of renal macrophages in monitoring and clearing off intratubular particles
He, J.; Cao, Y.; Zhu, Q.; Wang, X.; Cheng, G.; Wang, Q.; Han, F.; Shi, P.; Shen, X. Z.
Show abstract
During the filtrate of the glomerulus flows though the renal tubular system, a variety of microscopic sediment particles, including mineral crystals resulting from urine concentration, are generated. Dislodging these particles in the intratubular compartment is critical to ensure free flow of filtrate and the final formation of urine. However, the underlying mechanism for the clearance is unclear. Here, using high-resolution microscopy, we uncovered that the juxtatubular macrophages in the medulla constitutively formed transepithelial protrusions and were "sampling" urine contents. These behaviors were strengthened in the development of nephrolithiasis. In particular, the juxtatubular macrophages were efficient in sequestering and phagocytosing intraluminal sediment particles, and occasionally making transmigration to the tubule lumen to escort the excretion of urine particles. Specific depletion of renal macrophages precipitated kidney stone formation and aggravated the accompanied inflammation upon hyperoxaluria challenge. Thus, renal macrophages undertake a specific role in maintaining the tubular system unobstructed.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair 95%
- Kidney organoids: A system to study human basement membrane assembly in health and disease 94%
- The orchestrated cellular and molecular responses of the kidney to endotoxin define the sepsis timeline 94%
Similar papers in this journal
- Wwp2 Mediates The Metabolic Reprogramming Of Renal Myofibroblasts To Promote Kidney Fibrosis 95%
- Single Cell Profiling of Acute Kidney Injury Reveals Novel Transcriptional Signatures, Mixed Identities and Epithelial-to-Stromal Crosstalk 95%
- Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease. 95%
Similar papers in this journal
- PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression 95%
- Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis 94%
- Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization 94%
Similar papers in this journal
- Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice 94%
- A Novel Human Distal Tubuloid-On-A-Chip Model For Investigating Sodium And Water Transport Mechanisms 92%
- Deficiency of peroxisomal L-bifunctional protein (EHHADH) causes male-specific kidney hypertrophy and proximal tubular injury in mice 92%
Similar papers in this journal
- The transcription factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development 95%
- Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease 93%
- Cystinosin deficient rats recapitulate the phenotype of nephropathic cystinosis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.