Delta/ Omicron and Omicron/BA.2 co-infections occurring in Immunocompromised hosts
Leuking, R.; Narasimhan, M.; Mahimainathan, L.; mut, A.; Liu, Y.; Xing, C.; Larsen, C.; Clark, A. E.; SoRelle, J. A.
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Concomitant infection of multiple SARS-CoV-2 variants has become an increasing concern, as this scenario increases the likelihood of recombinant variants. Detecting co-infection of SARS-CoV-2 variants is difficult to detect by whole genome sequencing approaches, but genotyping methods facilitate detection. We describe 2 cases of Delta/Omicron and 2 cases of Omicron sublineage BA.1/ BA.2 co-infection as detected by a multiplex genotyping fragment analysis method. Findings were confirmed by whole genome sequencing. Review of the patient characteristics revealed co-morbidities and conditions which weaken the immune system and may make them more susceptible to harboring SARS-CoV-2 variant co-infections.
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