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CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion
2022-04-02
allergy and immunology
Title + abstract only
View on medRxiv
Show abstract
Chimeric antigen receptor (CAR) T cells have demonstrable efficacy in treating B-cell malignancies. Factors such as product composition, lymphodepletion and immune reconstitution are known to influence functional persistence of CAR+ T cells. However, little is known about the determinants of differentiation and phenotypic plasticity of CAR+ T and immune cells early post-infusion. We report single cell multi-omics analysis of molecular, clonal, and phenotypic profiles of CAR+ T and other immune c...
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