The phospholipase VlsPLA2 from the plant pathogen Verticillium longisporum is a virulence factor targeting host nuclei and suppressing PTI-related hypersensitive response
Rafiei, V.; Velez, H.; Tzelepis, G.
Show abstract
Phospholipases A2 (PLA2) are lipolytic enzymes, responsible for phospholipids hydrolysis. The role of PLA2 in various aspects of cell physiology has been shown, but their involvement in host-microbe interactions remains to be elucidated. The present study investigated the biological function of the secreted VIsPLA2 phospholipase in the phytopathogenic fungus Verticillium longisporum with emphasis on its role in host-microbe interactions. The VlsPLA2 was highly induced in V. longisporum during interaction with host plant Brassica napus, encoding an active phospholipase A2. VlsPLA2-overexpression V. longisporum strain showed an increased virulence on Arabidopsis plants, plausibly by inducing virulence factors. Furthermore, VIsPLA2 are transported to the nucleus, by hijacking VAMPA proteins, causing suppression of PTI-induced hypersensitive response, possibly by modulating the expression of genes involved in plant immunity. In summary, VlsPLA2 acts as a virulence factor by hydrolyzing the hosts nuclear envelope phospholipids, an action that induces signaling cascade, suppressing basal plant immunity responses.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- RLP23 is required for Arabidopsis immunity against the grey mould pathogen Botrytis cinerea 97%
- Apoplastic effector candidates of a foliar forest pathogen trigger cell death in host and non-host plants 97%
- Genome-wide identification and characterization of Solanum tuberosum BiP genes reveals the role of the promoter architecture in BiP gene diversity 95%
Similar papers in this journal
- A Jacalin-like lectin-domain-containing protein of Sclerospora graminicola act as an apoplastic virulence effector in plant-oomycete interactions 94%
- Genome-wide alternative splicing profiling in the fungal plant pathogen Sclerotinia sclerotiorum during the colonization of diverse host families 94%
- Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi 94%
Similar papers in this journal
- Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum 96%
- Guanosine-specific single-stranded ribonuclease effectors of a phytopathogenic fungus potentiate host immune responses 95%
- Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity 94%
Similar papers in this journal
- A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins 95%
- Chickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action 95%
- Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes 94%
Similar papers in this journal
- Unfolded protein response and scaffold independent pheromone MAP kinase signalling control Verticillium dahliae growth, development and plant pathogenesis 95%
- Fungal jasmonate as a novel morphogenetic signal for pathogenesis 95%
- UhAVR1, an HR-triggering avirulence effector of Ustilago hordei, is secreted via the ER-Golgi pathway to the cytosol of barley coleoptile cells and contributes to virulence early in infection. 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.