COVID-19 patients have increased levels of membrane-associated and soluble CD48
Pahima, H.; Zaffran, I.; Ben-Chetrit, E.; Jarjoui, A.; Gaur, P.; Manca, M. L.; Reichmann, D.; Orenbuch-Harroch, E.; Puxeddu, I.; Zinner, C.; Tzankov, A.; Levi-Schaffer, F.
Show abstract
COVID-19 is a respiratory-centered systemic disorder caused by SARS-CoV-2. The disease can progress into a severe form causing acute lung injury. CD48 is a co-signaling receptor, existing as both membrane-bound and soluble forms reported to be dysregulated in several inflammatory conditions. Therefore, we reasoned that CD48 could be deregulated in COVID-19 as well. Here we analyzed CD48 expression in autoptic sections and peripheral blood leukocytes and sera of COVID-19 patients by gene expression profiling (HTG(R) autoimmune panel), immunohistochemistry, flow cytometry and ELISA. Lung tissue of COVID-19 patients showed increased CD48 mRNA expression and infiltration of CD48+ lymphocytes. In the peripheral blood, mCD48 was considerably increased on all evaluated cells, and additionally, sCD48 levels were significantly higher in COVID-19 patients independently of disease severity. Considering the alterations of mCD48 and sCD48, a specific role for CD48 in COVID-19 can be assumed, suggesting it as a potential target for therapy.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Persistent oxidative stress and inflammasome activation in CD14 high CD16 - monocytes from COVID-19 patients 96%
- Plasma gradient of soluble urokinase-type plasminogen activator receptor is linked to pathogenic plasma proteome and immune transcriptome and stratifies outcomes in severe COVID-19 96%
- Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen requirements 95%
Similar papers in this journal
- Altered increase in STAT1 expression and phosphorylation in severe COVID-19 94%
- Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency 93%
- Maturation signatures of conventional dendritic cell subtypes in COVID-19 reflect direct viral sensing 92%
Similar papers in this journal
- Defective NET Clearance contributes to sustained FXII Activation in COVID-19-associated Pulmonary Thrombo-Inflammation 93%
- Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms 93%
- Survey of extracellular communication of systemic and organ-specific inflammatory responses through cell free messenger RNA profiling in mice 93%
Similar papers in this journal
- Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in human tissues and immune cells in health and disease 97%
- Caspases in COVID-19 Disease and Sequela and the Therapeutic Potential of Caspase Inhibitors 94%
- Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRP 94%
Similar papers in this journal
- Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure 94%
- Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19 93%
- FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.