Integrated protein and transcriptome high-throughput spatial profiling
Ben Chetrit, N.; Niu, X.; Swett, A. D.; Sotelo, J.; Jiao, M. S.; Roelli, P.; Stoeckius, M.; Landau, D. A.
Show abstract
Spatial transcriptomics and proteomics have independently transformed our understanding of complex biological processes; however, integration of these modalities is currently limited. To overcome this challenge, we developed Spatial PrOtein and Transcriptome Sequencing (SPOTS) for high-throughput integration of transcriptome and protein profiling within the spatial context. Applying SPOTS to spleen and breast cancer samples revealed that spatially-resolved multi-omic integration provides a comprehensive perspective on key biological processes in health and disease.
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