Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase
van Muijlwijk, G. H.; Bröring, E.; van Mierlo, G.; Jansen, P. W.; Vermeulen, M.; Aerts, P. C.; van Putten, J. P.; Palm, N. W.; de Zoete, M. R.
Show abstract
Akkermansia muciniphila is considered a key constituent of a healthy gut microbiota. In inflammatory bowel disease (IBD), A. muciniphila has a reduced abundance while other, putative pathogenic, mucus colonizers bloom. We hypothesized that interbacterial competition may contribute to this observation. By screening the supernatants of a panel of enteric bacteria, we discovered that a previously uncharacterized Allobaculum species potently inhibits the growth of A. muciniphila. Mass spectrometry analysis identified a secreted Allobaculum sialidase as inhibitor of A. muciniphila growth. The sialidase targets sialic acids on casein O-glycans, thereby altering the accessibility of nutrients critical for A. muciniphila. The altered glycometabolic niche results in distorted A. muciniphila cell division and efficiently arrests its growth. The identification of a novel mechanism of A. muciniphila growth inhibition by a competing bacterial pathobiont may provide a rationale for interventions aimed at restoring and maintaining a healthy microbiota symbiosis in patients with intestinal disease.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Secreted Aeromonas GlcNAc binding protein GbpA stimulates epithelial cell proliferation in the zebrafish intestine 96%
- Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation 94%
- Fusobacterium sphaericum sp. nov., isolated from a human colon tumor, adheres to colonic epithelial cells and induces IL-8 secretion 94%
Similar papers in this journal
Similar papers in this journal
- Human gut Faecalibacterium prausnitzii deploy a highly efficient conserved system to cross-feed on β-mannan-derived oligosaccharides 95%
- Identification of two glycosyltransferases required for synthesis of membrane glycolipids in Clostridioides difficile 95%
- BonA from Acinetobacter baumannii forms a divisome-localized decamer that supports outer envelope function 94%
Similar papers in this journal
- Protozoan predation enhances stress resistance and antibiotic tolerance in the opportunistic pathogen Burkholderia cenocepacia by triggering the SOS response 94%
- Exploring the interaction network of a synthetic gut bacterial community 94%
- Infant diet promotes Bifidobacterium community cooperation within a single ecosystem 94%
Similar papers in this journal
- The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species 96%
- A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917 95%
- Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.