Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia
Christie, I. N.; Theparambil, S. M.; Doronin, M.; Hosford, P. S.; Brazhe, A.; Hobbs, A.; Semyanov, A.; Abramov, A. Y.; Angelova, P.; Gourine, A. V.
Show abstract
In low oxygen conditions, increases in cerebral blood flow maintain brain oxygen delivery but the mechanisms underlying hypoxia-induced dilations of cerebral vasculature are incompletely understood. Here we show that astrocytes accumulate nitrite and in response to hypoxia produce nitric oxide via mitochondrial reduction of nitrite by a molybdenum-containing enzyme sulfite oxidase. These data suggest that astrocytes can modulate cerebral blood flow in accord with brain tissue oxygenation via mitochondrial production of nitric oxide.
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