B cells are addicted to immunoglobulin production in the ER
Caganova, M.; Taskiran, H.; Zong, Y.; Zach, A.; Kabrani, E.; Schmidt, K.; Goffing, P.; Jellusova, J.; Rajewsky, K.
Show abstract
Resting B cell dependence on the B cell antigen receptor (BCR) has been attributed solely to its signaling competence. We have recently shown that the presence of the BCR is vital for endoplasmic reticulum (ER) homeostasis and mitochondrial function both in primary B cells and Burkitt lymphoma (BL) cell lines. Unexpectedly, in BL Ramos cells this role has been shown to be independent of BCR signals from the cell membrane. Now, we provide evidence that also in mouse resting B cells ER-resident immunoglobulin (Ig) heavy chains control ER homeostasis, calcium storage and mitochondrial homeostasis through ER-mitochondria contacts. These findings demonstrate that BCR expression shapes cellular fitness already at the stage of assembly in the ER and uncover a new layer of B cell dependence on the production of Ig heavy chains in the ER. Sensing protein expression in the ER, with counterselection of compromised cells, might well operate also in other differentiated cells.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s. 94%
- Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition 94%
- Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis 93%
Similar papers in this journal
Similar papers in this journal
- Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells 97%
- Polypyrimidine Tract Binding Proteins are essential for B cell development 97%
- Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells 96%
Similar papers in this journal
- Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. 98%
- The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression 96%
- Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus 96%
Similar papers in this journal
- RUNX1 controls the dynamics of cell cycle entry of naive resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation 96%
- CPT2 mediated fatty acid oxidation is dispensable for humoral immunity 96%
- B cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.