Type I interferons govern Zika virus resistance of human macrophages and microglia
Hanrath, A. T.; Hatton, C. F.; Gothe, F.; Browne, C.; Vowles, J.; Leary, P.; Cockell, S. J.; Cowley, S. A.; James, W. S.; Hambleton, S.; Duncan, C. J. A.
Show abstract
The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Therapeutic manipulation of the IFN-I system may bring clinical benefit in ZIKV.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites. 96%
- B cells engineered to express an anti-HIV antibody allow memory retention, class switch recombination and clonal selection in mice 95%
- Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains 95%
Similar papers in this journal
- Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium. 94%
- IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections 94%
- Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set 94%
Similar papers in this journal
Similar papers in this journal
- Multimerization of Zika Virus-NS5 causes a ciliopathy and forces premature neurogenesis 96%
- Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to the human brain evolution 93%
- Robust three-dimensional expansion of human adult alveolar stem cells and SARS-CoV-2 infection 93%
Similar papers in this journal
- HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells 96%
- Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation 95%
- Extremely potent monoclonal antibodies neutralize Omicron and other SARS-CoV-2 variants 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.