Stem cell regulators control a G1 duration gradient in the plant root meristem
Echevarria, C.; Desvoyes, B.; Marconi, M.; Franco-Zorrilla, J. M.; Lee, L.; Umeda, M.; Sablowski, R.; Birnbaum, K. D.; Wabnik, K.; Gutierrez, C.
Show abstract
In meristems, where new plant organs initiate, key stem cell regulators have been identified, but their link to cell cycle progression remains unclear. Here, we show that the root meristem has a positional gradient of G1 duration that ranges from [~]2 h near the meristem boundary to more than 20 h in stem cells and early derivatives. Mutants in the PLETHORA (PLT) genes shortened G1 length and flattened its gradient. Computer modeling of an incoherent feed-forward loop (IFFL) predicted the inference of a negative regulatory pathway. We propose that PLT genes play opposing roles, maintaining meristem and stem cell activity and inhibiting G1 progression through the CDK inhibitor KRP5, a PLT target, and RBR1. This establishes a previously undescribed proximal-distal feature of the root meristem in which a G1 duration gradient is shaped by stem cell and meristem maintenance regulators.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Metaphloem development in the Arabidopsis root tip 97%
- Heterogeneous identity, stiffness and growth characterise the shoot apex of Arabidopsis stem cell mutants 96%
- HD-Zip II transcription factors control distal stem cell fate in Arabidopsis roots by linking auxin signaling to the FEZ/SOMBRERO pathway 96%
Similar papers in this journal
- Ectopic assembly of an auxin efflux control machinery shifts developmental trajectories 97%
- De novo stem cell establishment in meristems requires repression of organ boundary cell fate 96%
- Spatial transcriptional signatures define margin morphogenesis along the proximal-distal and medio-lateral axes in complex leaf species Solanum lycopersicum (tomato) 95%
Similar papers in this journal
Similar papers in this journal
- Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways 96%
- Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula 96%
- RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections 96%
Similar papers in this journal
- A morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root 98%
- Distinctive and complementary roles of E2F transcription factors during plant replication stress response 95%
- The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.