Levels of p53 expression determine the competitive ability of embryonic stem cells during the onset of differentiation.
Perez Montero, S.; Bowling, S.; Perez-Carrasco, R.; Rodriguez, T. A.
Show abstract
During development, the rate of tissue growth is determined by the relative balance of cell division and cell death. Cell competition is a fitness quality control mechanism that contributes to this balance by eliminating viable cells that are less-fit than their neighbours. What mutations confer cells with a competitive advantage or the dynamics of the interactions between winner and loser cells are not well understood. Here, we show that embryonic cells lacking the tumour suppressor p53 are super-competitors that eliminate their wild-type neighbours through the direct induction of apoptosis. This elimination is context dependant, as does not occur when cells are pluripotent and is triggered by the onset of differentiation. Furthermore, by combining mathematical modelling and cell-based assays we show that the elimination of wild-type cells is not through a competition for space or nutrients, but instead is mediated by short range interactions that are dependent on the local cell neighbourhood. This highlights the importance of the local cell neighbourhood and the competitive interactions within this neighbourhood for the regulation of proliferation during early embryonic development.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Wnt-and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division 96%
- Transcriptional Heterogeneity and Cell Cycle Regulation as Central Determinants of Primitive Endoderm Priming. 95%
- Notch controls the cell cycle to define leader versus follower identities during collective cell migration. 94%
Similar papers in this journal
- Signalling pathway crosstalk stimulated by L-proline drives differentiation of mouse embryonic stem cells to primitive-ectoderm-like cells 94%
- Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion. 94%
- Human neural progenitors establish a diffusion barrier in the ER membrane during cell division 94%
Similar papers in this journal
- A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation 94%
- Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry 94%
- Gene regulatory network (GRN) embedded agents connect cellular decision making to human pluripotent stem cell derived germ layer-like pattern formation 94%
Similar papers in this journal
- Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival 94%
- Dynamic remodelling of cadherin contacts in embryonic mesenchymal cells during differential cell migration 93%
- Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.