Transertion is used for localized expression and assembly of Vibrio parahaemolyticus T3SS2
Kaval, K. G.; Chimalapati, S.; Seigel, S.; Rodriguez, N. G.; Dalia, A. B.; Orth, K.
Show abstract
Using environmental cues, bacteria commit to the assembly of transmembrane complexes such as the type III secretion system 2 (T3SS2), a membrane-bound, syringe-like secretory apparatus used during infection to inject host cells with virulence factors. Here we report Vibrio parahaemolyticus uses transertion, localized transcription, translation, and membrane insertion, to assemble its T3SS2. Upon binding bile acids, the membrane bound receptor and transcription factor VtrA/VtrC captures the T3SS2 pathogenicity island at the inner membrane. Activated VtrA/VtrC induces production of VtrB, the membrane bound master T3SS2 transcriptional regulator. VtrB then induces the membrane-proximal T3SS2 genes to undergo transertion for assembly of the membrane inserted secretion machinery. Transertion is a process that can be used for the efficient assembly of membrane-bound molecular complexes in response to extracellular signals. One-Sentence SummaryLocalized transcription, translation, and membrane insertion of multi-protein complexes in bacteria in response to host cues.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Quorum sensing employs a dual regulatory mechanism to repress T3SS gene expression 95%
- PopB-PcrV Interactions are Essential for Pore Formation in the Pseudomonas aeruginosa Type III Secretion System Translocon 95%
- Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection 95%
Similar papers in this journal
- A quorum sensing-regulated type VI secretion system containing multiple nonredundant VgrG proteins is required for interbacterial competition in Chromobacterium violaceum 96%
- Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus 96%
- Molecular and evolutionary basis of O-antigenic polysaccharide driven phage sensitivity in environmental pseudomonads 94%
Similar papers in this journal
Similar papers in this journal
- Systematic analyses of factors required for adhesion of Salmonella enterica serovar Typhimurium to corn salad (Valerianella locusta) 94%
- A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi 94%
- Phenylacetyl-CoA, not phenylacetic acid, attenuates CepIR-regulated virulence in Burkholderia 2 cenocepacia 94%
Similar papers in this journal
- Enterococcus faecium sagA mutants have cell envelope defects influencing antibiotic resistance and bacteriophage susceptibility 95%
- Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth 94%
- Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.