Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phase
PAROUSH, Z.; Bar-Cohen, S.
Show abstract
The cell cycle depends on a sequence of steps that are triggered and terminated via the synthesis and degradation of phase-specific transcripts and proteins. While much is known about how stage-specific transcription is activated, less is understood about how inappropriate gene expression is suppressed. In this paper we demonstrate that Groucho, the Drosophila orthologue of TLE1 and other related human transcriptional corepressors, regulates cell cycle progression in vivo. We show that although Groucho is expressed throughout the cell cycle, its activity is selectively inactivated by phosphorylation, except during S-phase when it represses e2f1 expression. Misregulated Groucho activity causes cell cycle arrest; in particular, both constitutive Groucho activity and failure to repress e2f1 cause cell cycle arrest phenotypes. We also show that the Cdk1 kinase is responsible for stage-specific phosphorylation of Groucho in vivo. We propose that Groucho and its orthologues play key roles in the metazoan cell cycle that may explain the links between TLE corepressors and several types of human cancer.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling 96%
- Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations 96%
- The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis 96%
Similar papers in this journal
- Reduction of nucleolar NOC1 accumulates pre-rRNAs and induces Xrp1 affecting growth and resulting in cell competition in Drosophila 96%
- Wash and the WASH Regulatory Complex function in Nuclear Envelope budding 96%
- The dual Ras Association (RA) Domains of Drosophila Canoe have differential roles in linking cell junctions to the cytoskeleton during morphogenesis 96%
Similar papers in this journal
- Membrane potential regulates Hedgehog signaling and compartment boundary maintenance in the Drosophila wing disc 96%
- Protein phosphatase 1 regulates core PCP signaling 96%
- Non-apoptotic caspase activation sustains ovarian somatic stem cell functions by modulating Hedgehog-signalling and autophagy. 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.