period Translation as a Core Mechanism Controlling Temperature Compensation in an Animal Circadian Clock
Itoh, T. Q.; Yildirim, E.; Surabhi, S.; Braun, R.; Allada, R.
Show abstract
The most enigmatic of the canonical properties of circadian clocks is temperature compensation where circadian period length is stable across a wide temperature range despite the temperature dependence of most biochemical reactions. While the core mechanisms of circadian clocks have been well described, the molecular mechanisms of temperature compensation are poorly understood especially in animals. A major gap is the lack of temperature compensation mutants that do not themselves unambiguously affect the temperature dependence of the encoded protein. Here we show that null alleles of two genes encoding components of a complex important for translation of the core clock component period in circadian pacemaker neurons robustly alter the temperature dependence of circadian behavioral period length. These changes are accompanied by parallel temperature dependent changes in oscillations of the PER protein and are consistent with the model that these translation factors mediate the temperature-dependence of PER translation. Consistent with findings from modeling studies, we find that translation of the key negative feedback factor PER plays an instrumental role in temperature compensation.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79 91%
- Genetic screens identified dual roles of MAST kinase and CREB within a single thermosensory neuron in the regulation of C. elegans thermotaxis behavior 90%
- G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae 90%
Similar papers in this journal
- Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered Region 92%
- Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster. 92%
- Molecular mechanisms for environmentally induced plasticity in the positioning of meiotic recombination at hotspots 91%
Similar papers in this journal
- Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain 95%
- Gene drive that results in addiction to a temperature sensitive version of an essential gene triggers population collapse in Drosophila 92%
- Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.