Occurrence and significance of Omicron BA.1 infection followed by BA.2 reinfection
Stegger, M.; Edslev, S. M.; Sieber, R. N.; Ingham, A. C.; Ng, K. L.; Tang, M.-H. E.; Alexandersen, S.; Fonager, J.; Legarth, R.; Utko, M.; Wilkowski, B.; Gunalan, V.; Bennedbaek, M.; Byberg-Grauholm, J.; Moeller, C. H.; Christiansen, L. E.; Svarrer, C. W.; Ellegaard, K.; Baig, S.; Johannesen, T. B.; Espenhain, L.; Skov, R.; Cohen, A. S.; Larsen, N. B.; Soerensen, K. M.; White, E. D.; Lillebaek, T.; Ullum, H.; Krause, T. G.; Fomsgaard, A.; Ethelberg, S.; Rasmussen, M.
Show abstract
The newly found Omicron SARS-CoV-2 variant of concern has rapidly spread worldwide. Omicron carries numerous mutations in key regions and is associated with increased transmissibility and immune escape. The variant has recently been divided into four subvariants with substantial genomic differences, in particular between Omicron BA.1 and BA.2. With the surge of Omicron subvariants BA.1 and BA.2, a large number of reinfections from earlier cases has been observed, raising the question of whether BA.2 specifically can escape the natural immunity acquired shortly after a BA.1 infection. To investigate this, we selected a subset of samples from more than 1,8 million cases of infections in the period from November 22, 2021, until February 11, 2022. Here, individuals with two positive samples, more than 20 and less than 60 days apart, were selected. From a total of 187 reinfection cases, we identified 47 instances of BA.2 reinfections shortly after a BA.1 infection, mostly in young unvaccinated individuals with mild disease not resulting in hospitalization or death. In conclusion, we provide evidence that Omicron BA.2 reinfections do occur shortly after BA.1 infections but are rare.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- From elimination to suppression: genomic epidemiology of a large Delta SARS-CoV-2 outbreak in Aotearoa New Zealand 94%
- Post-peak dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 93%
- Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance 93%
Similar papers in this journal
- Higher risk of SARS-CoV-2 Omicron BA.4/5 infection than of BA.2 infection after previous BA.1 infection, the Netherlands, 2 May to 24 July 2022 95%
- The impact of early public health interventions on SARS-CoV-2 transmission and evolution 95%
- From more testing to smart testing: data-guided SARS-CoV-2 testing choices 92%
Similar papers in this journal
- Chasing the origin of SARS-CoV-2 in Canada's COVID-19 cases: A genomics study 93%
- In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 92%
- COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: two prospective observational cohort studies 91%
Similar papers in this journal
- Intra-host Variation and Evolutionary Dynamics of SARS-CoV-2 Population in COVID-19 Patients 91%
- Life identification number (LIN) codes for the genomic taxonomy of Corynebacterium diphtheriae strains 91%
- Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies 90%
Similar papers in this journal
- The emergence, spread and vanishing of a French SARS-CoV-2 variant exemplifies the fate of RNA virus epidemics and obeys the Black Queen rule 94%
- Culture and identification of a “Deltamicron” SARS-CoV-2 in a three cases cluster in southern France 92%
- Robust clinical detection of SARS-CoV-2 variants by RT-PCR/MALDI-TOF multi-target approach 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.