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Best of intent, worst of both worlds: why sequentially combining epidemiological designs does not improve signal detection in vaccine safety surveillance
2022-02-22
epidemiology
Title + abstract only
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BackgroundVaccine safety surveillance commonly includes a serial testing approach with a sensitive method for "signal generation" and specific method for "signal validation." Whether serially combining epidemiological designs improves both sensitivity and specificity is unknown. MethodsWe assessed the overall performance of serial testing using three administrative claims and one electronic health record database. We compared Type I and II errors before and after empirical calibration for histo...
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