A single cell atlas of the cycling murine ovary
Morris, M. E.; Meinsohn, M.-C.; Chauvin, M.; Saatcioglu, H. D.; Kashiwagi, A.; Sicher, N. A.; Nguyen, N.; Yuan, S.; Stavely, R. G.; Hyun, M.; Donahoe, P. K.; Sabatini, B. L.; Pepin, D.
Show abstract
The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary. Folliculogenesis and follicle progression require the orchestrated response of a variety of cell types to allow the maturation of the follicle and its sequela, ovulation, corpus luteum (CL) formation, and ovulatory wound repair. Little is known about the cell state dynamics of the ovary during the estrous cycle, and the paracrine factors that help coordinate this process. Herein we used single-cell RNA sequencing to evaluate the transcriptome of > 34,000 cells of the adult mouse ovary and describe the transcriptional changes that occur across the normal estrous cycle and other reproductive states to build a comprehensive dynamic atlas of murine ovarian cell types and states.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice 97%
- Luteinizing hormone stimulates ingression of granulosa cells within the mouse preovulatory follicle. 96%
- The Requirement of Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in Mouse Ovarian Development and Fertility 95%
Similar papers in this journal
- Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos 97%
- N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation 95%
- The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy 95%
Similar papers in this journal
- Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles 97%
- The estrogen receptor α cistrome in human endometrium and epithelial organoids 96%
- The luteinizing hormone receptor knock-out mouse as a tool to probe the in vivo actions of gonadotropic hormones/receptors in females 94%
Similar papers in this journal
Similar papers in this journal
- Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment 97%
- Single-cell transcriptomic profiling of the neonatal oviduct and uterus reveals new insights into upper Müllerian duct regionalization 96%
- Single cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.