An ancient role for the Hippo pathway in axis formation and morphogenesis
Brooun, M.; Salvenmoser, W.; Dana, C.; Sudol, M.; Steele, R.; Hobmayer, B.; McNeill, H.
Show abstract
How did cells of early metazoan organisms first organize themselves to form a body axis? The canonical Wnt pathway has been shown to be sufficient for induction of axis in Cnidaria, a sister group to Bilateria, and is important in bilaterian axis formation. Here, we provide experimental evidence that in cnidarian Hydra the Hippo pathway regulates the formation of a new axis during budding upstream of the Wnt pathway. The target of Hippo pathway, the transcriptional co-activator YAP, inhibits the initiation of budding in Hydra, and is regulated by Hydra LATS. In addition, we show functions of Hippo pathway in regulation of actin organization and cell proliferation in Hydra. We hypothesize that Hippo pathway served as a link between continuous cell division, cell density and axis formation early in metazoan evolution.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Lamprey Lecticans Link New Vertebrate Genes to the Origin and Elaboration of Vertebrate Tissues 94%
- The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development 94%
- Heterochronically expressed midline netrin was recruited to guide mesoderm migration in epibolic gastrulation of the leech 93%
Similar papers in this journal
- Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure 94%
- The neuroblast timer gene nubbin exhibits functional redundancy with gap genes to regulate segment identity in Tribolium 94%
- Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity 94%
Similar papers in this journal
- The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning 96%
- Tracking N-and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles 95%
- A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1 95%
Similar papers in this journal
- Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo 95%
- Cep97 Is Required For Centriole Structural Integrity And Cilia Formation In Drosophila 95%
- The transmembrane proteins M6 and Anakonda cooperate to initiate tricellular junction assembly in epithelia of Drosophila 95%
Similar papers in this journal
- A microRNA that controls the emergence of embryonic movement 94%
- Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion 94%
- GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.