Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography: First-in-human study
Wang, J. B.; Bruss, J.; Oya, H.; Uitermarkt, B. D.; Trapp, N. T.; Gander, P. E.; Howard, M. A.; Keller, C. J.; Boes, A.
Show abstract
Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the first in-human study evaluating the effects of TMS using intracranial electrocorticography (iEEG) in neurosurgical patients. We first evaluated safety in a gel-based phantom. We then performed TMS-iEEG in 20 neurosurgical participants with no adverse events. Next, we evaluated brain-wide intracranial responses to single pulses of TMS to the dorsolateral prefrontal cortex (dlPFC) (N=10, 1414 electrodes). We demonstrate that TMS preferentially induces neuronal responses locally within the dlPFC at sites with higher electric field strength. Evoked responses were also noted downstream in the anterior cingulate and anterior insular cortex, regions functionally connected to the dlPFC. These findings support the safety and promise of TMS-iEEG in humans to examine local and network-level effects of TMS with higher spatiotemporal resolution than currently available methods.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity. 96%
- Personalized whole-brain activity patterns predict human corticospinal tract activation in real-time 96%
- Characterizing and minimizing the contribution of sensory inputs to TMS-evoked potentials 96%
Similar papers in this journal
- A Practical Preprocessing Pipeline for Concurrent TMS-iEEG: Critical Steps and Methodological Considerations 97%
- Predictive modeling of TMS-evoked responses: Unraveling instantaneous excitability states 97%
- Effects of tDCS Dose and Electrode Montage on regional cerebral blood flow and motor behavior 97%
Similar papers in this journal
- Electrical stimulation of temporal and limbic circuitry produces distinct responses in human ventral temporal cortex 97%
- Signatures of electrical stimulation driven network interactions in the human limbic system 97%
- Transcutaneous vagus nerve stimulation in humans induces pupil dilation and attenuates alpha oscillations 96%
Similar papers in this journal
- A biophysically constrained brain connectivity model based on stimulation-evoked potentials. 96%
- Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data 96%
- The rt-TEP tool: real-time visualization of TMS-Evoked Potential to maximize cortical activation and minimize artifacts 95%
Similar papers in this journal
- Transcranial focused ultrasound to rIFG improves response inhibition through modulation of the P300 onset latency 95%
- Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory 95%
- Spatially bivariate EEG-neurofeedback can manipulate interhemispheric rebalancing of M1 excitability 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.